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Coahoma County is a county located in the Mississippi Delta region of the U.S. state of Mississippi. As of 2010, the population was 26,151. Its county seat is Clarksdale.
Coahoma County was established February 9, 1836, and is located in the northwestern part of the state in the fertile Yazoo Delta region. The name "Coahoma" is a Choctaw word meaning "red panther".