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Humphreys County is a county located in the U.S. state of Mississippi, in the Mississippi Delta region. In 2010, the population was 9,375. Its county seat is Belzoni.
It is named for Benjamin Grubb Humphreys (August 26, 1808 - December 20, 1882), an American politician from Mississippi. He was a general in the Confederate States Army during the American Civil War and served as Governor of Mississippi from 1865 to 1868, during Reconstruction.